There are several factors that should be considered when setting up a CNC machine, including:

1. Workpiece material: The material of the workpiece will affect the cutting parameters, such as speed, feed rate, and cutting tool. The operator should have knowledge about the properties of the material and adjust the machine accordingly.
2. Cutting tool: The cutting tool should be chosen based on the material of the workpiece and the desired surface finish. The operator should ensure that the cutting tool is sharp and in good condition.
3. Workholding: The workpiece should be securely held in place during the machining process. The operator should ensure that the workholding device is properly adjusted and tightened.
4. Coolant: Coolant can help to reduce heat and prolong the life of the cutting tool. The operator should ensure that the coolant system is properly set up and functioning.
5. Machine calibration: The machine should be calibrated before starting the machining process. This includes checking the level of the machine and the linear scales, making sure that the machine is square, and ensuring that the spindle is running true.
6. Tool offsets: The operator should set the tool offset values correctly, this will help the machine to know the exact position of the tool in relation to the workpiece.
7. Safety Measures: The operator should check that all the necessary safety measures are in place, such as guarding, emergency stops, and locking devices.
8. Programs: The operator should load the correct program into the machine, check that it is running properly, and make any necessary adjustments before starting the machining process.

It’s important to note that the setup process can be different depending on the specific type of CNC machine, so it’s essential that the operator has a good understanding of the machine and its capabilities, as well as the workpiece and the desired outcome.